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Chaperones attempt to remedy the unfolded protein first and, if unsuccessful, activate cellular programs, including the UPR, heat shock response (HSR), and ER-associated degradation (ERAD), to induce processes to either fix the problem or destroy the unfolded proteins (324, 325)

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Although the prevailing hypotheses for the cause of diet-associated DCM is too much of a dietary factor, the lack of grains and the compounds they provide (e.g., benzoates) could also complement a dietary factor excess

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1994;15 Suppl:s287-94

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