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Based on their safety, probiotics seem worth a try for these uses

(PMC) Not well supported: That AOD-9604 produces durable, clinically meaningful fat loss in modern standards (especially compared with GLP-1s)

Evidence Tier Framework Tier 1 FDA-approved therapy large randomized trials Tier 2 human trials demonstrating biological effect Tier 3 small human studies or limited clinical data Tier 4 animal models or anecdotal reports Stacking should generally involve: at least one Tier 1 therapy no more than one Tier 3 compound Stacks composed entirely of Tier 34 compounds should not be considered clinical protocols

The peptide appears to enhance cellular resistance to oxidative stress, chemical damage, and other insults

doi:10.1001/jama.1938.02790090004002

But the mechanism most people miss is oxidation, not just temperature