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Ibuprofen dosing is targeted to achieve a peak plasma level of 50 mcg/mL to 100 mcg/mL

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Instead, AA147-dependent protection against glutamate-induced oxidative toxicity is primarily mediated through compound-dependent activation of the NRF2 oxidative stress response

doi:10.1038/nature14344 Dolma S, Lessnick SL, Hahn WC, Stockwell BR (2003) Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells