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In our study, we observed the senescence of RPE cells despite the concomitant induction of autophagy following GSH depletion

Glutathione biosynthesis Glutathione (GSHis) is a reduced nonprotein thiol, which is present in all mammalian tissues and has important antioxidant and detoxification functions

Wagner F (1965) Reactions of the cyano and alkyl cobalamins

writingoriginal draft preparation, S.V

When Nrf2 responses are inadequate, lipid peroxides can trigger inflammation through the nuclear factor kappa B (NF-B) pathway ( NF-B functions as a principal modulator of inflammatory processes (Nowak and Relja, 2020)

This is a strong dose