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NANOG metabolically reprograms tumor-initiating stem-like cells through tumorigenic changes in oxidative phosphorylation and fatty acid metabolism

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This is achieved by inhibiting the protein PTEN and activating the PI3K/AKT/mTOR and PI3K/AKT/GSK3 pathways, as well as preventing the movement of vascular smooth muscle cells (Figure 2) (32, 33)