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Chronic cases involving significant ligament laxity typically require targeted treatment to address the underlying mechanical cause

Reactive oxygen species (ROS) and reactive nitrogen species (RNS) contribute to physiological activities required for appropriate cellular function, as well as pathological processes that affect energy generation, apoptosis, or mitophagy

However, some preservatives, especially benzalkonium chloride, have been associated with irreversible ciliary damage and have raised safety concerns for chronic use in intranasal preparations (Jiao and Zhang, 2019)

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