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10.1371/journal.pcbi.1010519 108 RichardsS

Ans) Nausea is a common side effect of the medicine but not at severity

Week 1 2

Mitochondrial dysfunction, as induced by neurotoxicants, such as 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and rotenone, augments oxidative stress in nigral neurons [16, 28]

Inclusion criteria required participants to be over age 18, read and speak English, have a Hoehn & Yahr score between 2 and 3 (bilateral disease, not severely disabled), and have three or more of the required positive criteria for the diagnosis of definite PD from Step 3 of the UK Brain Bank Diagnostic Criteria for PD

In the Nrf2/ARE pathway, LBP significantly increases the activity of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), scavenges excessive reactive oxygen species (ROS), stabilizes mitochondrial membrane potential (MMP), and reduces cytochrome C release (26, 27)