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Gastrointest Endosc 1999;49:599604

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Increased levels of fission genes (e.g., Drp1 and Fis1) and decreased levels of fusion genes (e.g., OPA1, Mfn1, and Mfn2) promote mitochondrial fragmentation and ROS overproduction [110, 111]

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liver and kidney function as well as a cell blood count were assessed in blood and urine at weeks 0 and week 12

We surmise that these early alterations could contribute to HFD-induced insulin resistance observed in longer protocols