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Additionally, studies have examined how a lack of melatonin affects specific brain functions, such as the regulation of sphingolipid turnover in the hippocampus, which suggests that melatonin is involved in maintaining a balance of lipids, and that this equilibrium may be compromised in aging organisms (Tchekalarova et al

TABLE 1 Effect of phytic acid on liver function assessment in mice serum of different study groups

In both male and female GHRKO mice, disruption of the GH/IGF-1 axis from birth results in mice that are remarkably long lived, but temporal disruption of this pathway in young adults (aGHRKO mice) improves lifespan only in females 17 , an observation which is consistent with the beneficial effects of targeting IGF-1R signaling post-development on female healthspan and aging in this study

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