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Glutathione but not dTTP level determines JMF4073 susceptibility Next, we investigated whether the decrease in dTTP pool by SHMT2 knockdown could induce DNA replication stress and increase susceptibility to JMF4073 in T315I-Bcr-Abl-32D cells

Dose-limiting toxicity has not been precisely defined in humans, yet practitioners should terminate infusions if severe dizziness, chest tightness, or abrupt blood-pressure drops occur, then reassess electrolyte status and acid-base balance before re- challenge

These sites not only move closer in IFnarrow but also rotate to occlude the non-functional ATP-binding site in NBD1 (Fig

Monitor your levels closely and speak with your provider about lowering doses of those drugs if needed

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