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PMC 2035923

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A decreased HoloTC level along with an increase in the size of the red blood cells (macrocytosis) is a good measure of vitamin B12 deficiency
As a consequence, the authorization is based on human clinical trials from the BA.1 shots, which produced a better immune response than the original doses, according to the FDA

Several small observational studies and case series have reported that GLP-1 receptor agonists can produce meaningful additional weight loss in patients experiencing weight regain or inadequate initial weight loss following bariatric procedures
