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Arendash GW, Schleif W, Rezai-Zadeh K, Jackson EK, Zacharia LC, Cracchiolo JR et al (2006) Caffeine protects Alzheimers mice against cognitive impairment and reduces brain beta-amyloid production

Careful and detailed psychological observation of the boys for four and eight weeks revealed the efficacy of L-carnitine treatment because significantly positive correlations between serum increased free and total L-carnitine levels and improvement in cognitive functions were found

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However, a potent and subtype-selective PPARdelta agonist called GW501516 has been developed using combinatorial chemistry and structure-based drug design

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