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Leske MC (2009) Ocular perfusion pressure and glaucoma: clinical trial and epidemiologic findings

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Three-times-weekly dosing (Monday, Wednesday, Friday) remains popular, especially for subcutaneous injection
Drawing 7.5 units on a 30-unit syringe is more precise than on a 100-unit syringe

Similar to loop and thiazide diuretics, it can also increase the uric acid levels resulting in hyperuricemia

Following the availability of data from these various studies, and data on c-MET expression as a biomarker that indicates a poor prognosis in patients with gastrointestinal cancer and increased c-MET expression, inhibitors targeting this pathway have entered the clinic in the past decade
