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Fishbein AB, Hamideh N, Lor J, Zhao S, Kruse L, Mason M, et al

GLS encoded kidney-type glutaminase is the 669 amino acid isoform 1 protein and GLS encoded glutaminase C is the 598 amino acid isoform 2 protein

Interim results from the NCT04886001 trial demonstrated clinical efficacy of the combination: it significantly improved cognitive function in early AD patients (assessed by ADAS-Cog13, with enhanced effects in APOE4-negative subgroups) and reduced CSF p-tau pathology compared with placebo, alongside an acceptable safety profile

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