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Published results have reported mean body weight reductions of approximately 20-22% from baseline at the highest studied doses exceeding published results for semaglutide at comparable timepoints

These drugs include exenatide (Byetta, short-acting

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Glucagon receptor activation modulates hepatic glucose output pathways in in-vitro assay systems, enabling research into receptor interactions not accessible with GLP-1R/GIPR-only reference standards

The majority of these reports are in women who were taking a GLP1RA agent for treatment of T2DM and stopped the medication during the first trimester (although in one instance the medication was continued through to term of pregnancy)

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