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In UK clinical settings, the recognised standard diluent for injectable medicines is Water for Injections BP (single-use, preservative-free), and the choice of diluent must always follow the licensed product's Summary of Product Characteristics (SmPC)

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Discontinue use and consult a doctor if adverse reactions occur

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The elderly (reduced absorption) Pernicious anemia Vegetarians / Vegans (low dietary B12) People taking metformin or acid reflux medications (PPIs) Post-bariatric or gastric-bypass patients Genetic variants in MTRR , MTR , or TCN2 What Has B12 Been Studied For