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10.1038/s41593-023-01476-4 Nat

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We also found that in elderly testes, nuclear-FOXO4 + Leydig cells expressed less 3-hydroxysteroid dehydrogenase (3-HSD), the rate-limiting enzyme in testosterone synthesis, than nuclear-FOXO4 - Leydig cells (Figure 2D)

Thalamocortical dysfunction and dysrhythmia in chronic pain demonstrated that CLBP pathophysiology and clinical pain intensity are associated with distinct thalamocortical network dynamics