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British Journal of Haematology, 62: 712
Mild redness (less than 3 cm, fading within hours): Cold compress for 10 minutes No additional treatment needed Monitor for expansion Moderate redness (3 to 5 cm, lasting 1 to 3 days): Cold compress every 2 to 3 hours for first 24 hours Hydrocortisone 1% twice daily Ibuprofen 200 to 400mg if uncomfortable Significant redness (more than 5 cm, warm to touch, lasting more than 3 days): Cold compress protocol as above Hydrocortisone 1% twice daily Oral antihistamine daily Ibuprofen 400mg every 6 hours If not improving by day 5, contact healthcare provider Tracking the size of redness helps determine whether a reaction is improving or worsening
Side effect profiles are similar in type (GI effects dominate both) but different in severity
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doi:10.1007/s00415-019-09282-4 Heckmann JG, Urban PP, Pitz S, Guntinas-Lichius O, Ggyor I
