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In the REDEFINE 1 trial, CagriSema produced 20.4% body weight loss over 68 weeks

Initial assessments (week 2) revealed a disrupted arrangement of sciatic nerve fibers in the non-conductive group, as well as axonal swelling, and extensive myelin fragmentation, indicative of varying stages of Wallerian degeneration in non-ES groups

Patients with ALS have a higher percentage of oxidized CoQ10

The preclinical data are interesting enough to warrant proper human investigation, but it is not sufficient to justify self-experimentation

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