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Overall, 63 patients were included in the study: the response rate was 63.5%

e , Reduced glutahione (GSH) and oxidized glutahione (GSSG) levels in naive CD4 + and CD8 + T cells from the indicated dietary groups, measured by metabolomics ( n = 6 per group)

The intracellular concentrations of vitamin B12 can be inferred through the total plasma concentration of homocysteine, which can be converted to methionine through an enzymatic reaction that uses 5-methyltetrahydrofolate as the methyl donor group

Scenario 2: Vitamin D Deficiency with Osteoporosis Patient Case: A 60-year-old male presents with chronic bone pain and fractures

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For the optic nerve crush rat models, the RGC shows a reduction of GPX4 and SLC7A11 expression, increased membrane density, reduced mitochondrial cristae, and increased lipid peroxide and iron levels, indicating RGC ferroptosis after optic nerve crush (Guo et al., 2022)