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Preclinical studies continuously predicted its usefulness to prevent cytokine storm, to prevent COVID coagulopathy, and as an antiviral drug (Liu and Ying, 2020

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Inhibition of PP2A activity can lead to protein hyperphosphorylation in neurons such as tau protein, neurofilament protein, and other proteins

Additionally, it plays a key role in detoxifying the liver by supporting the breakdown and removal of toxins

Furthermore, this systemic inflammation frequently crosses the blood-brain barrier, leading to profound neuroinflammation

The effect of melatonin on hypertrophic scar and keloid formation in clinical settings remains uncertain due to the inherent variability in scar development, the complexity of the underlying pathogenesis, and limitations in measurement and predictive methods