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Once diagnosed, it progresses into advanced hepatocellular carcinoma that is extremely resistant to treatment and has unsatisfactory therapeutic results

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[DOI] [PMC free article] [PubMed] [Google Scholar] 163.Ma L & Cheng Q Inhibiting 6-phosphogluconate dehydrogenase reverses doxorubicin resistance in anaplastic thyroid cancer via inhibiting NADPH-dependent metabolic reprogramming

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For context, ice extents for 2012 (the record low extent) and 2016 (another year with a slow refreeze) are also charted