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For example, in Alzheimer's disease research, transgenic mice that overexpress human APP and PS1 genes can simulate core pathological characteristics such as amyloid plaque deposition and neuron death, becoming a basic model for analyzing pathogenesis and testing drugs

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[1] Aizawa K et al

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[DOI] [PubMed] [Google Scholar] 219.Shimizu MH, Coimbra TM, de Araujo M, Menezes LF, Seguro AC

( d ) Representative flow cytometry plots of CD8 T cells and ( e ) M45 + virus specific CD8 T cells from chimeric mice infected with MCMV, vCD44BP (day 7 PI) or uninfected controls