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The composition of the BCG cell wall is highly immunogenic (8) due to the large amount of Toll-like receptor 2 (TLR2) ligands, such as lipomannan (9), dimannoside (PIM 2 ) and hexamannoside (PIM 6 ) phosphatidylinositol mannosides (10), as well as muramyl dipeptide derivatives which can also activate TLR4 (11) or nucleotide-binding oligomerization domain-containing protein 2 (NOD2) (12)

The terms aging and cellular senescence cannot be used interchangeably

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J Stress Physiol Biochem 10(1):93111 Sadak MH, Rady MM, Badr NM, Gaballah MS (2010) Increasing sunflower salt tolerance using nicotinamide and -tocopherol

Furthermore, epithelial cells with mutated NOD2, have an inappropriate response to a sensor of a cell wall component of Gram-positive bacteria (muramyl dipeptide, MDP) whose stimulation determines the production of pro-inflammatory mediators (338341)