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Intriguingly, SP and L-car significantly reduced FOXO1 expression in the POI rat model, together with P53 and caspase-3 downregulation

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Furthermore, the study examined the impact of TMAO pretreatment on chemosensitivity, demonstrating that higher concentrations of TMAO (200 M) notably reduced the apoptotic response of PCa cells to chemotherapeutic agents, including docetaxel (76)

[DOI] [PubMed] [Google Scholar] 40.Masuda D, Hirano K, Oku H, Sandoval JC, Kawase R, Yuasa-Kawase M, Yamashita Y, Takada M, Tsubakio-Yamamoto K, Tochino Y, Koseki M, Matsuura F, Nishida M, Kawamoto T, Ishigami M, Hori M, Shimomura I, Yamashita S

Early, small trials suggested a beneficial effect of ALCAR with respect to cognitive decline (98-100), whereas later, larger trials found little-to-no effect compared to placebo (101-103)