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One proposed mechanism involves modulation of neurotransmitter systems in the brain, particularly GABAergic, opioidergic, serotonergic, and dopaminergic pathways that are known to regulate sleep, arousal, mood, and stress responses

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e.g., they are significantly lower (orange fit in Figure 3e) and comparable (green fit in Figure 3e) to those obtained for the protic solvents methanol or formamide

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