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Transforming growth factor (TGF-) is a multifunctional factor that plays a diverse role in cell growth and differentiation
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Thus, TNBS promotes two independent mechanisms of injury, GSH depletion and ROS generation, both being required for the manifestation of mucosal injury as GSH limitation renders intestine susceptible to the TNBS-induced ROS overgeneration

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However, in MDM, the redox status has not been evaluated non-invasively during the disease progression
