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Atherosclerosis 2002 Jan

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This adverse metabolic profile may further exacerbate cardiovascular risk by increasing oxidative stress and endothelial dysfunction, as androgen-mediated activation of metabolic pathways alters myocardial energy balance and redox homeostasis (73)

674,679,680 Likewise, NOME perfusion is cardioprotective in a heart ischemia/reperfusion injury model

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However, for substitutions and other purposes, they don't: a hydroxyl "at 3" is on carbon 15 (4th from the end), not 16
