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Lipolysis: pathway under construction

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Violaxanthin de-epoxidase (VDE) Violaxanthin de-epoxidase (VDE) is a plant-specific enzyme in the lipocalin family which uses ascorbate as reductant in the de-epoxidation of the xanthophyll pigment violaxanthin to produce zeaxanthin [150]

13465477.10.1038/nrn3257 Nat

More into details, our group could demonstrate that this alteration of negative surface charge of HDL could be attributed to the presence of a positively charged, lysine-rich cluster in the C-terminal helix of human apoC1, and blocking these amino-acid residues through chemically induced acetylation was associated with a significant decrease in the inhibitory effect of apoC1 on CETP [100]

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