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doi: 10.1001/jama.290.13.1763
doi: 10.1530/REP-24-0117 82
Preclinical rodent studies have shown that transplanted dopaminergic neurons from human fetal mesencephalic grafts can innervate the dopamine-deprived striatum, receive inputs from host neurons, and diminish rotational behavioral symptoms
Overall, preclinical studies have shown that NAD + and mitochondrial metabolism play a crucial and intertwined role in aging and age-associated diseases, as well as being possible therapeutic targets for ameliorating these conditions
