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Redox Control of Protein Function Although classical signaling pathways depend on macromolecular interactions, mild oxidants such as H 2 O 2 signal through chemical reactions with functional groups of target proteins, resulting in covalent protein modifications at the atomic level

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doi: 10.1074/jbc.M109.010868

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Epigenetic drift and altered gene expression NAD+ shortage drives epigenetic changes by reducing sirtuin activity