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The intravenous mode of delivery is intrusive and causes the patient inconvenience, increased medical expenses, and therapeutic side effects (like central venous catheter issues) when receiving extended care

226 ONOO reacts with thiols, metals, and CO, generating oxidants such as NO 2 and CO 3

These results suggest that hydrogen rich saline is effective in combating renal ischemia and reperfusion injury [17]

Then, a treatment of the crude reaction by H 2 O 2 at 0 C gives a mixture of 9( E )-9-NOME 32 and 9( E )-10-NOME 31 , that can be separated by HPLC (Scheme 68)

However, the studies that have examined these potential therapies have not been conducted in ASD