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An excess of Fe 2+ leads to the production of ROS through the Fenton reaction, which induces cell damage or death and potentially impairs organ function eventually

If ineffective quenching of this triplet excited chlorophyll ( 3 Chl*) occurs, it will undergo a redox reaction with 3 O 2 liberated during the splitting of water in the oxygen-evolving complex (OEC), producing 1 O 2 (Li et al., 2009)

Third, IGF-1 has anti-apoptotic and anti-inflammatory effects, reducing cell death and inflammation in the cardiovascular system (De Giorgi et al., 2022)

10.1155/2019/9212314 157 ZhangN.XueL.YounasA.LiuF.SunJ.DongZ.et al (2022a)

Then, the synthetic parameters of pFeSAN were optimized to reach the highest activity

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