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Funding This work was financially supported by the National Natural Science Foundation of China (82100447, 81602327), the Fundamental Research Funds for the Central Universities (2242023K40035), and the Zhishan Scholars Programs of Southeast University (2242021R41070)

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Dietary supplementation or restriction of amino acids in worms, flies and mice modulates lifespan and health, which has been associated with changes in mitochondrial biogenesis, antioxidant response, as well as the activity of tricarboxylic acid cycle and respiratory chain

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