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Mato, J

Currently, four monoclonal antibodies are in clinical trials for the treatment of CD38 + malignancies [41-49]

Studies show that NNMT inhibition by 5-amino-1-methylquinolinium significantly reduces nicotinamide metabolism, increases NAM accumulation, improves NAD+ synthesis efficiency by over 30%, and markedly increases mitochondrial ATP production and cellular energy metabolism

However, this association does not imply causationelevated B12 often serves as a biomarker for serious underlying disease rather than being directly harmful

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