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CYP2D6 is highlighted as the main enzyme responsible for the metabolism of aripiprazole
This review synthesizes these multifaceted resistance pathways and parallels them with the challenges in vaccine development, highlighting the limited efficacy of Bacillus Calmette-Gurin and the promise of next-generation candidates

Substitution of three aromatic residues with threonine (W385T), tyrosine (F417Y), and alanine (W525A), present at the corresponding positions in EcGGT, resulted in enhanced transpeptidase activity for all three mutants, while a 514% decrease in hydrolytic activity was observed

This approach allowed us to capture a wide range of studies, from early foundational work to recent clinical trials, providing a balanced overview of the field