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This polymorphism is in intron 13 of the MAO-B gene and is thought to disrupt monoamine metabolism, leading to increased ROS production and oxidative stress within the central nervous system (Leko et al., 2021)
Patients often ask about why colchicine, which has been available in unbranded form for many years, is now a branded drug (Colcrys, Mitigare)
Published 2022 Sep 14
10.1046/j.1365-3059.2001.00605.x 102 WolstenholmeB
