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Water Solubility: Because it is highly water-soluble, it is best introduced in the aqueous phase of your formulation at a temperature below 40C to preserve its bioactivity

doi: 10.3390/ijms24032026

[DOI] [PMC free article] [PubMed] [Google Scholar] 61.Biteau B, Labarre J, Toledano MB

The authors concluded that while only one of eight variables (peak torque during knee extension) reached significance between placebo and patch groups and while two other variables resulted in near-significance, the inconsistency of the overall results did not provide a convincing argument that the energy patches were capable of enhancing performance (23)

[DOI] [PMC free article] [PubMed] [Google Scholar] 33.Falco L., Tessitore V., Ciccarelli G., Malvezzi M., DAndrea A., Imbalzano E., Golino P., Russo V

However, previous reviews emphasize common mechanistic pathways such as inflammation and oxidative stress while emerging pathways particularly autophagy-related signaling are under explored