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doi: 10.1038/S41598-022-07414-X 226 AntoniouKMVasarmidiERussellAMAndrejakCCrestaniBDelcroixMet al

If a horse or a rabbit is immunized with a specific phage strain, it produces an antiphage serum that can inactivate (neutralize) the specific phage, in the same way as an antidiphtheria serum can neutralize diphtheria toxin' (Sderqvist, 2003a

Targeted delivery and pharmacokinetic limitations The advancement of DAMP-targeted therapies encounters substantial pharmacological obstacles, especially in terms of target delivery and pharmacokinetic optimization, which considerably impede clinical translation

Targeting these dynamics may attenuate the epithelial damage and profibrotic microenvironment characteristic of IPF

Negatively charged nanoparticles, on the other hand, have better stability and lower immunogenicity (Wang et al., 2025c)

Timing: Administer 30 to 60 minutes before intended sleep, based on the IV half-life profile and the assumption that SC peak absorption lags IV by 15 to 30 minutes