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It has been recently published that in rats fed with a sucrose rich diet (which produce insulin resistance) a treatment with 50 mg/Kg of acetyl-L-carnitine and 25 mg/Kg of nicotinamide reduced the insulin resistance, increased the insulin secretion and normalized the blood glucose

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Tirzepatide, a GIPR/GLP1R coagonist, decreased sdLDL particles, apoB and apoCIII levels, along with increased serum LPL concentrations 151

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Carnitine is a vital transporter molecule whose function is to carry high-energy fat compounds into mitochondria, where they are "burned" to release their energy