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[28] have reported that the denaturation temperature of myofibrillar protein from oyster adductor muscle was about 46C, which was similar to the denaturation temperature of myofibrillar protein in this paper

And then it lead to body inflammation (Mittal et al., 2014), cellular damage and death (Dixon & Stockwell, 2014)

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ROS accumulation leads to LPO, protein oxidation, and DNA damage, ultimately impairing melanocyte survival [78]