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doi: 10.1002/art.27667 42 HuJWangHLiXLiuYMiYKongHet al

Beyond their capacity to dissect metabolic heterogeneity, emerging single-cell metabolomics, imaging mass spectrometry, and spatial transcriptomics platforms hold significant promise for biomarker discovery and patient stratification in NSCLC

PLGA and other biodegradable carriers can readily be functionalized with GSH-cleavable linkers or redox-sensing moieties, providing clinically tractable routes to translate GSH-responsive designs into precision treatments [23]

That this mechanism is indeed working is supported by the demonstration that while oxidation of the carbon skeleton of glutamate in the TCA cycle is dependent on activity of GDH (18), the formation of glutamate from -ketoglutarate is catalyzed by an aminotransferase which is most likely mitochondrial AAT (19)