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2005, 33: D223-D225

Consistent with this, the deletion alleles of multiple genes ( sms-1 , sms-2 , sms-3 , and sms-5 ) encoding sphingomyelin synthases, which are thought to disrupt sphingomyelin synthesis, completely suppressed the increase in synapses in ncr-2(0) mutants without causing any noticeable synaptic defects by itself (see the Materials and Methods section