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If you give a T4 medication (like Synthroid, Levoxyl, Unithroid, etc.) to someone with inflammation, its not going to work because they cant convert the T4 to T3

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Neuroprotective effect of the methanolic extract of hibiscus Asper leaves in 6-hydroxydopamine-lesioned rat model of parkinsons disease

However, its clinical application has been limited by dose-dependent gastrointestinal toxicity observed in later phase I and II clinical trials

The glutaredoxin and thioredoxin systems act in this process by activating transcription factors [180,181] and reducing ribonucleotide reductase for DNA synthesis [[182], [183], [184]]

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