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This is particularly an issue in pediatric populations, where tools for predicting drug efficacy and developmental toxicity are not well established

The biological activity of thiol groups (SH) in the side chain of Cys depends on the chemical properties of sulphur atoms, which play a key role in reversible redox reactions together with redox signalling (Considine and Foyer 2021)

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These abnormalities disrupt neuronal communication, leading to atrophy in areas such as the hippocampus and the neocortex, critical areas for learning and memory [70]

Although the main objectives of some clinical trials have not been met, many data indicate that this drug delays the progression of DMD (reviewed in: [82])