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Description
Cushing disease Cushing disease is caused by a primary activating pituitary pathology (usually neoplastic) that leads to continuous secretion of ACTH and -MSH into the blood stream

National Heart, Lung, and Blood Institute

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Illicit drug use may also cause unusual areas of pigmentation

2025 Mar 13;26(6):2578

Comparative Analyses of Pentraxins: Implications for Protomer Assembly and Ligand Binding
