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This study was supported by The National Natural Science Foundation of China (31300978)

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Figure 1 3 Phenotypes and endotypes of COPD The clinical phenotype of COPD refers to one or more disease characteristics that reflect differences among COPD patients and correlate with clinical outcomes

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The drug deferiprone has been shown to inhibit ferroptosis by chelating excess iron within the substantia nigra in vivo (52)

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