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In the latest tranche of published warning letters, the US Food and Drug Administration (FDA) has continued to go after drugmakers for marketing glucagon-like peptide-1 (GLP-1) receptor agonists and similar medications without regulatory approval

Zhao et al., 2025) that MSCs can not only directly differentiate into nucleus pulposus-like cells, replenishing the missing cell population (Li et al., 2025), but also play a key role through paracrine actions: on one hand, by secreting growth factors (such as TGF-, IGF-1) to activate anabolic pathways and promote ECM synthesis (Tang et al., 2025)

Mattei AE, Gutierrez AH, Martin WD, Terry FE, Roberts BJ, Rosenberg AS, De Groot AS

Leukocytoclastic vasculitis associated with TNF alpha inhibitors typically manifests as a cutaneous small-vessel vasculitis

Currently, the IRR seems to be a "safe switch." It is naturally designed to be turned on during injury

Representative images of Olig2 with high magnification inset of the medial CC showing cells after cpz treatment
