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Similarly, trastuzumab, a monoclonal antibody that binds HER2, is used to treat HER2-positive breast cancer but resistance is problematic [50] and in vitro studies with SKBR3 breast cancer cells implicate activated IGF-1R in this process [51], which is reversed by inhibition of IGF-1R [52]

This could lead to the mislocalization of key components of A generation in the axonal swellings, including amyloid precursor protein (APP) and enzymes that cleave APP such as beta secretase 1 and presenilin 1

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Conversely, cotreatment with CCCP and Mdivi-1 blocked CCCP-stimulated proliferation of cancer cells (Fig

Methods Biochem

Study of Orywal et al