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Apr 1990;70(4):1007-1013

More importantly, however, is to consider relative shifts in TW CCS N2, meas between a parent drug (or any precursor) and its corresponding metabolite rather than their absolute TW CCS N2, meas values: constant and discriminative relative mean shifts in TW CCS N2, meas values apparently exist as demonstrated for eight different phase I and II biotransformation which were not only obtained on precursor ion but also on fragment ion level

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Moreover, it was reported that supplementing the diet with the antioxidants N -acetylcysteine and vitamin E markedly increases tumor progression and reduces survival in mouse models of B-RAF- and K-RAS-induced lung cancer, by reduction of ROS, DNA damage, and p53 expression (Sayin et al., 2014)